dok_zlo (dok_zlo) wrote,
dok_zlo
dok_zlo

О совместимости...





Есть у нас один активно (я бы сказал агрессивно и навязчиво, но то таке) промотируемый чудо-препарат,, от всех болезней гепатопротектор, содержащий кроме витаминов, модного  цинка и ряда сверхэффективных веществ типа метионина и экстракта артишока, еще и экстракт грейпфрута.





В крайнее время, совести у промотируюющих  хватает добиваться от докторов назначения его параллельно курсу антимикробной терапии. Уважаемые коллеги, я понимаю запарка, ковид, карантин, и все такое... и проще назначить, "на всякий случай"..

Так вот в дан случае, это не тот случай.





Гуглим слово цитохром, и так далее...особенное если вы назначаете препараты действующие на анаэробную м/ф, или параллельно проводите антипротозойную, антимикотическую терапию (метронидазол, флуконазол, итраконазол и т.д) - не надо так.

А если пациент в силу сопутствующей патологии получает статины, антигипертензивные препараты - тем более не надо.


Что почитать:

[Spoiler (click to open)]

  • Adukwu E.C., Allen S.C., Phillips C.A. (2012) The anti-biofilm activity of lemongrass (Cymbopogon flexuosus) and grapefruit (Citrus paradisi) essential oils against five strains of Staphylococcus aureus. J. Appl. Microbiol., 113(5): 1217–1227.

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  • Sirovina D., Oršolić N., Gregorović G., Končić M.Z. (2016) Naringenin ameliorates pathological changes in liver and kidney of diabetic mice: a preliminary study. Arh. Hig. Rada Toksikol., 67(1): 19–24.

  • Takanaga H., Ohnishi A., Murakami H. et al. (2000) Relationship between time after intake of grapefruit juice and the effect on pharmacokinetics and pharmacodynamics of nisoldipine in healthy subjects. Clin. Pharmacol. Ther., 67(3): 201–214.

  • Varis T., Kivistö K.T., Neuvonen P.J. (2000) Grapefruit juice can increase the plasma concentrations of oral methylprednisolone. Eur. J. Clin. Pharmacol., 56(6–7): 489–493.

  • von Woedtke T., Schlüter B., Pflegel P. et al. (1999) Aspects of the antimicrobial efficacy of grapefruit seed extract and its relation to preservative substances contained. Pharmazie, 54(6): 452–456.

  • Xulu S., Oroma Owira P.M. (2012) Naringin ameliorates atherogenic dyslipidemia but not hyperglycemia in rats with type 1 diabetes. J. Cardiovasc. Pharmacol., 59(2): 133–141.отсюда










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